Bulgaria offers Ivermectin free of charge to its citizens, Phase 2 study,
natural herd immunity?, etc.
Egypt’s clinical trial + Tokyo Medical Assoc. chairman recommends Ivermectin:
Zimbabwe green lights importation of Ivermectin to treat COVID-19:
Belgian virologist believes we could eradicate COVID-19 in 6 weeks with Ivermectin:
Having multiple effective treatment and prevention agents is important even with the vaccines. But it becomes increasingly important in the light of possible (but still unknown) problems with new Coronavirus strains:
California’s coronavirus strain looks increasingly dangerous & may evade current vaccines
I am not a doctor and not an expert on Ivermectin. All drugs have side effects, but this one seems to be one of the safer ones. But, everyone needs to decide on their use of medications for themselves in consultation with their doctor.
Here are a few quotes and links:
“Ivermectin has continually proved to be astonishingly safe for human use. Indeed, it is such a safe drug, with minimal side effects, that it can be administered by non-medical staff and even illiterate individuals in remote rural communities, provided that they have had some very basic, appropriate training. This fact has helped contribute to the unsurpassed beneficial impact that the drug has had on human health and welfare around the globe, especially with regard to the campaign to fight [the river blindness parasite] Onchocerciasis.”
“Doses up to 2000 µg/kg are well tolerated in patients with parasitic infections, with analysis of the first 11 years of mass global ivermectin (Mectizan) administration indicating a cumulative incidence of one serious adverse side effect case per million. Similarly, although drug resistance can occur in animals, no resistance in humans has yet been confirmed in over 25 years. Based on this weight of evidence, ivermectin is unquestionably a safe, potent antiparasitic agent likely to be used as such long into the future.”
“An estimated 6 million people worldwide have taken ivermectin for various parasitic infestations. No serious drug-related adverse events have been reported. Side effects of ivermectin include fever, headache, chills, arthralgia, rash, eosinophilia, and anorexia. Many of these symptoms are thought to result from the death of parasites rather than as a reaction to the drug.
Ivermectin seems to be concentrated in the liver and fat tissue, with very low levels reaching the central nervous system.20 No significant drug interactions have been reported.
A study of elderly nursing home patients treated for scabies infection showed an increased death rate among ivermectin-treated patients, but it was noted that this finding has not been confirmed in multiple subsequent trials.”
Over 300 million people take ivermectin each year. To date, ivermectin has been shown to be a safe and well-tolerated drug. Most adverse reactions are mild and temporary, such as loss of appetite, headache, muscle aches, lack of energy, and fever. There have been a small number of severe adverse events and even some deaths in humans treated with ivermectin in onchocerciasis-control programs. The reason for these events is unknown, but they might be linked to the presence of large numbers of other parasites that are killed off in treated patients.
Is ivermectin safe and are there any contraindications for use?
The discovery of ivermectin in 1975 was awarded the 2015 Nobel Prize in Medicine given its global impact in reducing onchocerciasis (river blindness), lymphatic filiariasis, and scabies in endemic areas of central Africa, Latin America, India and Southeast Asia. It has since been included on the WHO’s “List of Essential Medicines with now over 4 billion doses administered.
Numerous studies report low rates of adverse events, with the majority mild, transient, and largely attributed to the body’s inflammatory response to the death of parasites and include itching, rash, swollen lymph nodes, joint paints, fever and headache. In a study which combined results from trials including over 50,000 patients, serious events occurred in less than 1% and largely associated with administration in Loa Loa infected patients.
Further, according to the pharmaceutical reference standard Lexicomp, the only medications contraindicated for use with ivermectin are the concurrent administration of anti-tuberculosis and cholera vaccines, while the anticoagulant warfarin would require dose monitoring.
Another special caution is that immunosuppressed or organ transplant patients who are on calcineurin inhibitors such as tacrolimus or cyclosporine or the immunosuppressant sirolimus should have close monitoring of drug levels when on ivermectin given that interactions exist which can affect these levels. A longer list of drug interactions can be found on the database of www.drugs.com/ivermectin.html, with nearly all interactions leading to a possibility of either increased or decreased blood levels of ivermectin.
Given studies showing tolerance and lack of adverse effects in human subjects given even escalating, high doses of ivermectin, toxicity is unlikely although a reduced efficacy due to decreased levels may be a concern. Finally, ivermectin has been used safely in pregnant women, children, and infants.
Can ivermectin be given to patients with acute or chronic liver disease?
In regards to liver disease, ivermectin is well tolerated, given that there is only a single case of liver injury reported one month after use that rapidly recovered. Ivermectin has not been associated with acute liver failure or chronic liver injury. Further, no dose adjustments are required in patients with liver disease.
Is Ivermectin to treat COVID really safe for everyone?
“We have previously reported on the mounting evidence for the effectiveness of ivermectin in the prophylaxis and treatment of covid-19 but now a report has been published that shows clearly the effects of mass distribution of ivermectin to whole provinces in Peru. The authorities in Peru acted very quickly to approve ivermectin and implement comprehensive distribution programmes – even including door-to-door visits.
As a result there is now a clear picture of what happens when a population of 33 million is treated with ivermectin. By chance, one province (Lima) implemented the mass treatment scheme several months later than all the others and so acted as a natural control.
On May 8th 2020 the Government of Peru authorised mass treatment of covid-19 with ivermectin. “Over the course of several months deaths due to covid-19 dropped 11-fold with the use of ivermectin. ….In November there was a new President who stopped using ivermectin and deaths went back up 12-fold”, explains Dr Scheim.
In Peru there are detailed records for every death in a national database and it was possible to analyse the data for the segment of the population over 60 years of age. “We looked at the data state by state and the results are stunning and conclusive”, says Dr Scheim.”